Changes in the Activity of the Limbic-Hypothalamic Neural Pathways Under the Repeated Immobilization Stress

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Changes in the electrical activity of the limbic-hypothalamic neural pathways during the process of adaptation to the immobilization stress were studied in the rabbit with chronically implanted electrodes. Both the hippocampally and the amygdaloidly evoked potentials in the medial basal tuberal region revealed decreases in their amplitudes during exposure to the 1st immobilization stress. Following the repeated exposure to the stress, the resting levels of their amplitudes decreased, and thus the decrease of amplitude in response to immobilization stress was reduced. To administered exogenous ACTH or cortisol acetate, those evoked potentials were significantly sensitive, and in the rabbit having been exposed to the repeated immobilization stress, the response to exogenous ACTH was observed to be altered.<BR>It was considered that the limbic-hypothalamic neural pathways played a role in the establishment of adaptation mechanism by changing their responsiveness to the stressful stimuli and to ACTH and/or adrenal corticoid during the repeated exoposure to stress.
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