Serum Thyrotropin Response to Thyrotropin Releasing Hormone and the Concentration of Thyroid Hormone in Patients with Hyperfunctioning Thyroid Nodule

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概要

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• Relationship between serum TSH response to TRH and serum thyroid hormone levels was studied in 8 patients with single hyperfunctioning nodule of thyroid. The results were variable. No or low response to 500μg TRH was observed in 6 subjects, 3 of whom were associated with evevated T<SUB>4</SUB> and T<SUB>3</SUB>, one with normal T<SUB>4</SUB> and elevated T<SUB>3</SUB> and two with normal T<SUB>4</SUB> and T<SUB>3</SUB>. Normal response was shown in other 2 subjects with normal T<SUB>4</SUB> and T<SUB>3</SUB>. Following administration of 2, 000μg TRH to 3 subjects with absence of response to 500μg TRH, 2 subjects with elevated T<SUB>4</SUB> and T<SUB>3</SUB> showed no response, but one with normal T<SUB>4</SUB> and T<SUB>3</SUB> showed low but definite response. After removal of the nodule, TSH response to TRH was increased in 3 subjects. Two of them was associated with decreased T<SUB>4</SUB> and T<SUB>3</SUB> but another one showed negligible changes in T<SUB>4</SUB> and T<SUB>3</SUB>. These findings may indicate that responsiveness of TSH to TRH in these patients is not solely dependent on circulating thyroid hormone levels.

• 社団法人 日本内分泌学会の論文

著者

• MIYAI Kiyoshi

  Clinical Pathology Osaka University Hospital

• Miyai Kiyoshi

  Central Laboratory For Clinical Investigation And Department Of Laboratory Medicine Osaka University

• Kumahara Yuichi

  Central Laboratory For Clinical Investigation Osaki University Hospital

• TAKAI SHINICHIRO

  Central Laboratory for Clinical Investigation, Central Laboratory for Clinical Investigation

• KUMA KANJI

  Central Laboratory for Clinical Investigation, Kuma Hospital

• AZUKIZAWA Mizuo

  Central Laboratory for Clinical Investigation, Second Department of Surgery

• ISHIBASHI KAICHIRO

  Central Laboratory for Clinical Investigation, Second Department of Surgery

• HOSOKAWA MITSUKO

  Central Laboratory for Clinical Investigation, Second Department of Surgery

• MIYAI KIYOSHI

  Central Laboratory for Clinical Investigation, Second Department of Surgery

• AZUKIZAWA Mizuo

  Central Laboratory for Clinical Investigation, Osaka University Hosbital

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