A Case of Oat Cell Carcinoma of the Lung Associated with Ectopic Production of ADH, Neurophysin and ACTH
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概要
- 論文の詳細を見る
A woman with oat cell carcinoma of the lung showed the typical findings of the syndrome of inappropriate secretion of ADH initially during her hospital course. Ectopic production of ADH was indicated. The presence of ectopic production of ACTH was then suggested after the appearance of the elevation of plasma cortisol and ACTH which was not suppressed by dexamethasone administration. The laboratory findings of metabolic alkalosis and hypokalemia were also consistent with hyperadrenocorticism. In tumor tissue obtained by biopsy, ACTH and ADH were proven to be present by radioimmunoassay as well as nicotine-stimulated-neurophysin and estrogen-stimulated-neurophysin. This was a rare case in which the simultaneous production of ADH and ACTH was clinically diagnosed. It is suggested that the elevation of neurophysins in plasma is of value in the diagnosis of ectopic production of ADH.
- 社団法人 日本内分泌学会の論文
著者
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Ishikawa San-e
Department Of General Internal Medicine Omiya Medical Center Jichi Medical School
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Saito Toshikazu
Departments Of Internal Medicine Social Insurance Central General Hospital
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KURATOMI YUSHIRO
Department of Endocrinology and Metabolism, Jichi Medical School
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Saito Toshikazu
Department Of Medicine Jichi Medical School
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Saito Toshikazu
Department Of Diabetes And Endocrinology Social Insurance Central General Hospital
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ISHIKAWA SAN-E
Department of Endocrinology and Metabolism, Jichi Medical School
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SAITO TOSHIKAZU
Department of Endocrinology and Metabolism, Jichi Medical School
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