Suppressive Effect of Pentagastrin on Pituitary-Adrenocortical Secretion

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概要

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• The effect of pentagastrin on the pituitary-adrenocortical secretion was examined in male rats. In the morning the intraperitoneal injection of this peptide produced a slight, but significant, decrease in the plasma corticosterone levels, but it had no effect on the evening rise due to circadian periodicity and the stress-induced elevation of the plasma corticosterone level. Following intracerebroventricular administration of pentagastrin, plasma corticosterone tended to decrease and in <I>in vitro</I> incubation of rat pituitary tissue the addition of pentagastrin elicited a suppressive effect on the ACTH release from the tissue into the medium. It was suggested that gastrinlike peptide might control the secretion of ACTH.

• 社団法人 日本内分泌学会の論文

著者

• Odaguchi Kunihiro

  Shionogi Research Laboratory Shionogi Co. Ltd.

• ITOH SHINJI

  Shionogi Research Laboratory

• HIROTA RYOJI

  Shionogi Research Laboratory

• KATSUURA GORO

  Shionogi Research Laboratory

• ODAGUCHI KUNIHIRO

  Shionogi Research Laboratory

関連論文

• Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Ostrich Adrenocorticotropic Hormone
• Suppressive Effect of Pentagastrin on Pituitary-Adrenocortical Secretion
• Circannual Variation of Mortality Rate Following a Single Injection of Hydrocortisone in Newborn Rats
• Selective reduction of enhanced sodium appetite of SHR by chronic intracerebroventricular administration of α-human atrial natriuretic polypeptide (α-hANP)
• Effect of neonatal hydrocortisone treatment on brain monoamines in developing rats.

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