合成ペプチド脂質 : 会合形態とその酵素機能モデルとしての反応場特性

概要

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Synthetic peptide lipids having amino acid residue (s), interposed between a polar head moiety and a hydrophobic double-chain segment as hydrogen-bonding component (s), constitute morphologically stable bilayer membranes in aqueous media. Relevant adjustment of the packing mode of lipid molecules results in the formation of nonbilayer structures, inverted cubic and hexagonal phases, which have been assumed as key intermediates in the membrane fusion, and these phases are evidently involved in the present dynamic fusion processes. Single-walled vesicles formed with the present peptide lipids are utilized as effective apoenzyme models for formation of artificial holoenzymes with various hydrophobic coenzyme models of NADH, vitamin B<SUB>6</SUB>, and B<SUB>12</SUB>.
社団法人有機合成化学協会の論文