水溶液中でのホスト-ゲスト相互作用

概要

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Paracyclophane macrocycles provide an effective binding site for hydrophobic substrates in aqueous media. There are two types of host-guest interactions for these macrocycles : inclusion of the hydrophobic moiety of a substrate into the macrocyclic cavity, and binding of a guest molecule by face-to-face hydrophobic interaction. A polyazaparacyclophane bearing long alkyl chains as branches of the skeleton provides a deeper hydrophobic cavity due to its octopus-like structure. In order to freeze up the molecular motion of an incorporated guest, additional interactions would be required. Paracyclophanes enhanced various organic reactions by covalent, general acid, general base, and acid-base bifunctional catalysis in addition to the hydrophobic effect exerted by them. Some recent progress in cyclodextrin chemistry has also been briefly reviewed.
社団法人有機合成化学協会の論文