置換ベンゼンスルホニル・カルバミン酸誘導体の研究(第2報) : N-置換ペンゼンスルホニルーN-アルキルクロルホルムアミジン体の新しい合成法

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It was found that N-tosyl-N-butyl-S-methylisothiourea reacted with phosphorus pentachloride to give the corresponding chlorof ormamidine, phosphorus trichloride, and methyl chloride. When the phosphorus pentachloride was replaced by chlorine, chlorof ormamidine and other product, presumably methyl sulf onyl chloride, were formed. N-Tosyl-N-butylthiourea, upon treatment with chlorine, also gave the correspo-nding chlorof ormamidine and sulfur dichloride. By means of such reactions, N-p-chlorobenzenesulfonyl-N -propyl-chloroformamidine was synthesized in a good yield. The chloroformamidines so obtained could readily be converted into the corres-ponding ureas, O-methylisoureas, and guanidines.
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