海水中のクロルテトラサイクリンの安定性および静菌効果

概要

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It has been well known fact that chlortetracycline (CTC) is very stable in acid solution but not in alkaline solution. The pH of sea water is near 8.0 or more, but it is obliged to use sea water for storage of fish aboard. The aims of this paper are to investigate the stability and the bacteriostatic effect of CTC in sea water. The results can be summarized as follows: 1. CTC was stable in sea water compared with CTC in phosphate buffer solution with pH 8.0 (Fig. 1). 2. The antibiotic was rapidly destroyed in effluent of sea water through a column of cation exchange resin (H), but very stable in percolate expelled with 2 N hydrochloric acid (Fig. 2). 3. CTC was stable in magnesium sulphate and calcium acetate solutions (Table 1). 4. Bacteriostatic effect of CTC in magnesium sulphate solution containing Mg++ at equal level to the cation in sea water was equal to that of CTC in sea water (Table 3). 5. Bacteriostatic and preservative effect of CTC in sea water were recovered by addition of citric acid (Table 2 and Figs. 3, 4). 6. CTC was very stable in sea water containing citric acid (Table 4).
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