ウナギにサルファ剤を与えた時の組織内濃度について

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The tissue concentrations of sulfamerazine given at the rate of 20 milligrams per 100 grams of fish per day were examined. The fishes weighing on the average 95.6 grams were kept in a concrete-pond and fed once a day with the drug-containing food at the rate of 10% of the fish-weight per day. The water-temperature was 27.5-33.4°C, average 30°C during the experiments. The treatment was continued for five successive days and the determinations were made with the composite samples of two fishes each, on the first to seventh day after the commencement of the treatment. The results (Table 1 and Fig. 1) showed the similar tendency to that of trout, which had been reported by SNIESZKO and FRIDDLE (1951). The blood concentrations of thiasin, sulfadiazine and sulfamerazine were measured in eels which received the intramuscular injection or oral administration of one dose of the drugs at the rate of preceding experiments. The results obtained are presented in Table 2.
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