Adipose Tissue-specific Expression of the Obese (ob) Gene in Rats and Its Marked Augmentation in Genetically Obese-hyperglycemic Wistar Fatty Rats.

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概要

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• The obese (ob) gene has recently been isolated by positional genetics, the mutation of which causes marked obesity and diabetes in mice. In the present study, we elucidated the tissue distribution of the ob gene expression in rats and examined the gene expression in genetically obese-hyperglycemic Wistar fatty rats. Northern blot analysis using the rat ob cDNA probe identified a single mRNA species of 4.5 kilobase in size in the adipose tissue, while no significant amount of ob mRNA was detected in other tissues in Sprague-Dawley and Wistar rats. The ob gene expression occurred in the adipose tissue with region-specificities. The rank order of the ob mRNA level in the adipose tissue was epididymal, retroperitoneal, and pericardial white adipose tissue > mesenteric and subcutaneous white adipose tissue ≥ interscapular brown adipose tissue in both rat strains. Furthermore, expression of the ob gene was augmented in all the adipose tissue examined in Wistar fatty rats at the stage of established obesity.

• 日本学士院の論文

著者

• Yoshimasa Yasunao

  Department Of Atherosclerosis And Diabetes National Cardiovascular Center

• Hosoda Kiminori

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

• Masuzaki Hiroaki

  Department Of Atherosclerosis And Diabetes National Cardiovascular Center

• Tamura Naohisa

  Department Of Applied Chemistry Faculty Of Engineering Gifu University

• Ogawa Yoshihiro

  Department Of Applied Life Sciences Niigata University Of Pharmacy And Applied Life Sciences

• Jingami Hisato

  Department Of Medicine And Clinical Science Kyoto University Graduate School Of Medicine

• Shigemoto Michika

  Department Of Endocrinology And Metabolism Rakuwakai Otowa Hospital

• Nakao Kazuwa

  Department Of Endcrinology And Metabolism Kyoto University Graduate School Of Medicine

• Hosoda Kiminori

  Department Of Endcrinology And Metabolism Kyoto University Graduate School Of Medicine

• MORI Kiyoshi

  Department of Critical Care Medicine, Iwate Medical University

• Satoh Noriko

  Department of Bio-system,Faculty of engineering,Yamagata University

• SATOH Noriko

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

• TAMURA Naohisa

  Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine

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