Protein Permeation through Polymer Membranes for Hybrid-type Artificial Pancreas.

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概要

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• Hydrogel membranes were prepared by radiation crosslinking of poly (vinyl alcohol) (PVA) in aqueous solutions. Effects of PVA concentration, PVA molecular weight, and radiation dose on the permeation of insulin and immunoglobulin through the membranes were investigated. Glucose permeation was also studied. The crosslinking density affected the size of macromolecular mesh of hydrogel network as well as the water content of membrane responsible for the diffusion of the solutes. The diffusion coefficient linearly increased for all the solutes with the increasing water content in PVA hydrogels, indicating that diffusion occurs primarily through the water hydrating the polymer network. The increase in crosslinking density of hydrogels by changing PVA molecular weight brought about the decrease in mesh size of the hydrogels, which, in turn, had an influence on the diffusion of immunoglobulin, but not of insulin and glucose.

• 日本学士院の論文

著者

• Ikada Yoshito

  Research Center For Bioengineering Faculty Of Medicine Kyoto University

• HATADA Motoyoshi

  Osaka Laboratory for Radiation Chemistry, Japan Atomic Energy Research Institute

• Fujisato Toshiya

  Research Center For Biomedical Engineering Kyoto University

• Hatada Motoyoshi

  Osaka Laboratories Japanese Association for Radiation Research on Polymers

• BURCZAK Krystyna

  Research Center for Biomedical Engineering, Kyoto University

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