Regionally different noradrenergic innervation and receptor distribution in submucous plexus of guinea-pig intestine
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概要
- 論文の詳細を見る
Regional differences of noradrenergic innervation and noradrenergic α2 receptor distribution in the submucous plexus of guinea-pig caecum, large intestine, and rectum were investigated with immunofluorescence confocal microscopy. In the caecal submucous plexus, three dimensional basket-like arrangements of small and bright dots of tyrosine hydroxylase-like immunoreactivity (TH-LIR) were observed, whereas noradrenergic α2A receptor-like immunoreactivity (NAR-LIR) was detected in somata. Both TH-LIR and NAR-LIR were localized in neuronal somata of the transverse colon. A few TH-LIR positive cell somata and many TH-LIR positive spots forming chains passing through ganglia and interganglionic nerve strands were observed, but no NAR-LIR were seen in the submucous plexus of the descending colon. There were a few TH-LIR positive somata and puncta, but no NAR-LIR were observed in the ascending colon and rectum. All of these observations show the distinct regional differences in noradrenergic innervation and noradrenergic α2A receptor distribution in the guinea-pig submucous plexus.
- 日本学士院の論文
著者
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Hirai Keiji
Department Of Autonomic Physiology Medical Research Institute Tokyo Medical And Dental University
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KATAYAMA Yoshifumi
Department of Autonomic Physiology, Medical Research Institute, Tokyo Medical and Dental University
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Kurihara K
Tohoku Univ. Miyagi
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Kurihara Ken
Department Of Cardiology Musashino Red Cross Hospital
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Katayama Yoshifumi
Department Of Applied Physics Faculty Of Engineering University Of Tokyo
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Hirai Keiji
Department Of Architecture Nishinippon Institute Of Technology
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KURIHARA Ken
Department of Autonomic Physiology, Medical Research Institute, Tokyo Medical and Dental University
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