STUDIES ON THE INFLUENCE UPON THE SUSCEPTIBILITY OF MICE TO VIRUS II Report.:Effect of cortisone on the susceptibility of mice to virus (2)
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概要
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In the previous report (1) we confirmed that relatively large dose of cortisone, when employed as a preliminary treatment, had promoted the susceptibility of mice to mouse encephalomyelitis virus. As cortisone shows a very wide action, an unitary understanding on the mechanism of its action has not yet been reached in spite of many studies. Therefore, at the present time the mechanism of the susceptibility increasing effect of cortisone to virus is still unknown. As we pointed out in the previous report, cortisone promoted not only the susceptibility of mice to virus but also the susceptibility to all common bacteria, so a possibility that a single medicine works on various different pathogenic microorganisms is considered to be very little. Southan et al (2) concluded that infection promoting eflect of cortisone must have been the action on the host and we think that this point is quite right.We understand quite well that adrenal cortex plays an important role on maintaining life, but we are very doubtful that cortisone shows very wide action. So we would like to conceive that cortisone may cause a chain reaction in living bodies. In order to solve this problem there is no other means but to study step by step. We believe that the solution of this problem will serve a great deal for analysis of virus susceptibility.In this report, we wish to report the result on the effect of cortisone upon the multiplication of virus in the brain and the condition of mice at the time of administeration of cortisone.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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NAKAGAWA YOH
Department of Microbiology, Kurume University School of Medicin
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KANDA YUKISHIGE
Department of Bacteriology, Kurume University School of Medicine
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