STRUCTURAL CHANGES OF THE RAT CHOROID PLEXUS FOLLOWING INTRAVENTRICULAR INJECTION OF SOME DRUGS:TRANSMISSION AND SCANNING ELECTRON MICROSCOPIC OBSERVATION

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概要

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• Ultrastructures of the choroid epithelium of the rats were examined by means of transmission and scanning electron microscopy after intraventricular injection of pilocarpine and puromycin. In the rats to which isotonic saline solution was injected, peculiar changes were not observed as composed with the rats without drug treatments. Pilocarpine injection produced structural changes suggestive of hyperfunction of the choroid cells. Their nuclei were oval in shape and the cytoplasmic organelles were extensively well-developed. Moreover, these cells possessed polypoidal microvilli with remakably expanded tips. On the other hand, puromycin injection caused structural changes suggesting degeneration or hypofunction of the choroid cells. Their nuclei showed irregular contour and the organelles were also depressed. The microvilli tended to have slender finger-like profile. In conclusion, the polypoid border which has been know as a characteristic of the choroid epithelium is not artifact in preparations but may be probably concerned with hyperfunction of this tissue.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• SHIMADA TATSUO

  Second Department of Anatomy, Kurume University School of Medicine

• INOKUCHI TETSUO

  Second Department of Anatomy, Kurume University School of Medicine

• OBAYASHI IKUO

  Second Department of Anatomy, Kurume University School of Medicine

• MURAKAMI MASAHIRO

  Second Department of Anatomy, Kurume University School of Medicine

関連論文

• STRUCTURAL CHANGES OF THE RAT CHOROID PLEXUS FOLLOWING INTRAVENTRICULAR INJECTION OF SOME DRUGS:TRANSMISSION AND SCANNING ELECTRON MICROSCOPIC OBSERVATION
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