Effects of atropine on nicotinic transmission in bullfrog sympathetic ganglia.
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Effects of atropine on nicotinic transmission in bullfrog sympathetic ganglia were examined by the intracellular microelectrode technique. The fast excitatory postsynaptic potential (fast EPSP) of ganglion cells recorded in Ca<SUP>2+</SUP> -deficient solution is depressed in the presence of atropine (3-30μM). The mean amplitude of fast EPSP is decreased to about 60% of normal with 30μM atropine. The quantal content calculated from these fast EPSPs by the variance method increases in the presence of atropine to 160% of normal with 30μM atropine. The amplitude of fast ACh-potential decreases to about 30% of normal, and that of miniature EPSPs decreases to about 35% of normal in the presence of atropine (30μM). Thus, it seems that atropine facilitates the evoked release of ACh from preganglionic nerve terminals in sympathetic ganglia.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
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