Effects of TRH and an Analog, DN-1417 on the Activities of Single Neurons in the Nucleus Accumbens, Cerebral Cortex and Caudate-putamen of Rats
スポンサーリンク
概要
- 論文の詳細を見る
The actions of TRH and its analog, γ - butyrolactone - γ -carbonylhistidyl prolinamide citrate (DN-1417) on the unit activities of the cerebral cortex, caudate -putamen and nucleus accumbens were examined using a microelectrophoretic technique in anesthetized rats. Over 80% of the neurons examined in the nucleus accumbens responded to TRH and DN -1417. The effects were mainly inhibitory, but excitatory effects (12-17%) were also detected. In the cerebral cortex and caudate -putamen, only one-third of the neurons were depressed by TRH and DN-1417. DN-1417 exerted an effect similar to TRH on almost all neurons. Dopamine affected almost all neurons. Its main effect was inhibition, but excitation was also observed in some neurons of the nucleus accumbens. Methamphetamine mimicked dopamine in the three regions. However, it was observed that TRH and DN-1417 mimicked dopamine only in the nucleus accumbens neurons. Furthermore, both the inhibitory and excitatory actions of TRH, DN -1417 or dopamine were attenuated by the dopamine receptor antagonist, haloperidol, which was administered systemically. These results suggest that : (1) TRH and DN -1417 have similar actions on the neurons; (2) TRH and DN-1417 act more selectively than dopamine and methamphetamine on the nucleus accumbens neurons, and they may act indirectly on dopaminergic neurons of the nucleus accumbens through an action on presynaptic sites; (3) Endogenous TRH may play a physiological role as a neuromodulator of dopaminergic transmission in the nucleus accumbens.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
Nagawa Yuji
Central Research Division Takeda Chemical Industries Ltd.
-
SAJI YOSHIAKI
Central Research Division, Takeda Chemical Industries Ltd.
-
HASHIMOTO TADATOSHI
Central Research Division, Takeda Chemical Industries Ltd.
-
FUKUDA NAOHISA
Central Research Division, Takeda Chemical Industries Ltd.
-
NAGAWA YUJI
Central Research Division, Takeda Chemical Industries Ltd.
関連論文
- MECHANISM OF ANTIPENTOBARBITAL ACTION OF THYROTROPIN-RELEASING HORMONE (TRH)
- BLOOD LEVEL AND BRAIN DISTRIBUTION OF THYROTROPIN-RELEASING HORMONE (TRH) DETERMINED BY RADIOIMMUNOASSAY AFTER INTRAVENOUS ADMINISTRATION IN RATS
- A TRH analog (DN-1417): Effects on local cerebral glucose utilization in conscious and pentobarbitalized rats determined by the autoradiographic 2-deoxy-(14C)glucose method.
- Increase in rat regional brain cyclic nucleotides by thyrotropin-releasing hormone (TRH) and its analog DN-1417.
- Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia.
- Effects of TRH and an Analog, DN-1417 on the Activities of Single Neurons in the Nucleus Accumbens, Cerebral Cortex and Caudate-putamen of Rats
- Effects of idebenone (CV-2619) on endogenous monoamine release and cyclic AMP formation in diencephalon slices from rats.
- Pharmacologic characterization of a novel non-benzodiazepine selective anxiolytic, DN-2327.
- Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats.
- A possible mechanism of action of thyrotropin-releasing hormone (TRH) and its analog DN-1417 on the release of dopamine from the nucleus accumbens and striatum in rats.
- In vivo electrochemical detection of 5-hydroxyindoles in the dorsal hippocampus of anesthetized rats treated with idebenone (CV-2619).