Effects of idebenone (CV-2619) on endogenous monoamine release and cyclic AMP formation in diencephalon slices from rats.
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概要
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The addition of CV-2619 (10<SUP>-4</SUP> M) stimulated the release of endogenous 5-hydroxytryptamine (5-HT) markedly and that of norepinephrine (NE) slightly from slices of rat diencephalon, but it did not affect dopamine (DA) release. The addition of CV-2619 (10<SUP>-5</SUP>-10<SUP>-4</SUP> M) or 5-HT (10<SUP>-6</SUP>-10<SUP>-4</SUP> M) stimulated cyclic AMP formation in a concentration-dependent manner. Methysergide (10<SUP>-4</SUP> M), a 5-HT receptor blocker, almost completely blocked CV-2619 (10<SUP>-4</SUP> M) and 5-HT (10<SUP>-4</SUP> M)-induced cyclic AMP formation. These results suggest that CV-2619 stimulates cyclic AMP formation via endogenous monoamine, particularly, 5-HT release.
- 公益社団法人 日本薬理学会の論文
著者
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NARUMI SHIGEHIKO
Central Research Division, Takeda Chemical Industries, Ltd.
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Nagawa Yuji
Central Research Division Takeda Chemical Industries Ltd.
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NAGAOKA Akinobu
Central Research Division, Takeda Chemical Industries, Ltd.
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