Anti-cholestatic and cytoprotective properties of ursodeoxycholic acid. Studies in vivo and vitro.:Studies in vivo and vitro

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In order to show the beneficial effect of urosodeoxycholic acid (UDCA) administration to patients with intrahepatic cholestasis, UDCA was given to intrahepatic cholestasis rat models and primary cultured rat hepatocytes.<BR>Oral administration of UDCA (20mg/kg) to rats with 17α-ethynyl estradiol-induced cholestasis improved biliary excretion of indocyanine green injected intravenously. Cytochemical study showed a better preservation of alkaline phosphatase in the bile canalicular membrane in UDCA treated rat.<BR>In cultured rat hepatocytes, the cytotoxicity induced by taurochenodeoxycholic acid was compromised by increasing the UDCA concentration in culture medium.<BR>These findings suggest that UDCA hampered the development of cholestasis by 17α-ethynyl estradiol and this effect was thought to be brought by the cytoprotective effect of UDCA against the CDCA induced cytotoxicity during the course of cholestasis.
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