Investigation of serum Cu, Zn-SOD concentration by ELISA and histological localization in hepatocellular carcinoma(HCC), liver cirrhosis(LC), and alcoholic liver injury using anti-human Cu, Zn-SOD monoclonal antibody.

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The serum Cu, Zn-SOD concentration and histological localization in patients with HCC, LC, and alcoholic liver injury were examined. The serum Cu, Zn-SOD concentration of patients with HCC was significantly elevated compared to healthy adults and also patients with LC. In about 20% of our specimens, tumors were strongly stained in comparison with the surrounding tissue. The main histological characteristic of LC was that Cu, Zn-SOD localized more in hepatocytes bordering on the connective tissue in the pseudolobular of some specimens. There was a tendency that this characteristic was more often in A and A' types than other types. In alcoholic liver injury, there were 3 Cu, Zn-SOD stain patterns such as "Diffuse Type", "Granular Type", and "Nuclear Type". There was a tendency for the specimens from heavy drinkers to be "Granular Type". These results suggest that it is possible for Cu, Zn-SOD to be a new marker for HCC and also to be a parameter for liver damage in chronic liver disease.