Effects of transcatheter arterial embolization on hepatocellular carcinoma. Analysis by multivariate logistic model and Cox's proportional hazard model.:Analysis by multivariate logistic model and Cox's proportional hazard model

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In order to evaluate what parameters are useful for the assessment of the effects of transcatheter arterial embolization (TAE) on hepatocellular carcinoma (HCC), 86 patients with HCC were investigated using the methods of multivariate analysis. 86 patients were classified into the two groups according to survival period after TAE; group I consisted of the patients who died in 12 months after TAE and group II consisted of the patients who survived over 12 months. The analysis by multivariate logistic model revealed that serum level of alphafetoprotein (AFP) was the most available parameter (t=2.3696) for the prediction of the prognosis after TAE, and was followed by the findings of abdominal CT (t=1.9398), the age (t=1.7502) and the percent occupation of HCC in the liver (t=1.6917) in this order. The analysis by Cox's proportional hazard model revealed that the survival rate was strollgly affected by the existence of ascites (t=4.2332), AFP (t=4.2090), the degree of tumor embolus in portal vein (t=2.9462) and Ch-E (t=2.6202). There was no relation between the morphological finding of HCC and the prognosis of the patients with HCC. These results led to conclude that the indication of TAE should be well discussed in the patients who had some of factors such as ascites, high AFP, embolus in portal vein and high age.
社団法人日本肝臓学会の論文