Enzyme histochemical observation of precursor lesions of hepatocellular carcinoma.

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Characteristic alterations of enzyme activity have been reported in precursor lesions of the experimental liver carcinogenesis. An enzyme histochemical technique of γ-GTP activity was used in the liver of 121 cases of autopsy and surgical materials on their whole cut specimen including the largest dimension of the organ in order to ascertain whether enzyme altered lesion exists in the human liver. The materials included 34 cases of hepatocellular carcinoma (HCC) with liver cirrhosis (LC), 18 cases of LC, 20 cases of chronic hepatitis and 49 cases of others. Seven enzyme altered lesions of the human liver were found in 4 cases, i.e. 2 HCC with LC, 1 chronic hepatitis and 1 others. Six of the altered lesions showed positive γ-GPT reaction and one was negative.<BR>It seems likely that enzyme histochemical technique of γ-GTP activity is supplementary valid for detection of HCC and precursor lesions in the human liver.