Studies on the metabolism of BSP conjugates in patients with obstructive jaundice.
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Sulfobromophthalein (BSP) 5mg/kg was injected as a bolus to 27 cases with obstructive jaundice.<BR>Blood and bile sumples were taken for 120 minutes in 10-15min interval and serum BSP was fractionated by sirica-gel chromatography. Bile was collected via PTCD.<BR>Three fractions of BSP were separated from serum and bile, which were identified as free (FBSP), cysteine conjugated (Cyst-BSP) and glutathione conjugated (GSH-BSP) BSPs.<BR>The higher the serum bilirubin, the lower was serum total BSP disappearance rate (K). The retention of serum BSP was attributed to an increase in Cyst-BSP, which account for some 75-82% of total BSP at 120 minutes after the administration.<BR>In the bile specimen, F-BSP and Cyst-BSP were the major components of total BSP.<BR>The results suggested that, in obstructive jaundice, the major conjugate of BSP which regurgitated in the blood stream and excreted into bile, is cysteine conjugated, due probably to an impaired metabolism of GSH-BSP.
- 社団法人 日本肝臓学会の論文
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