Histopathological features of non-A, non-B viral hepatitis.

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Comparative histopathological studies were performed among type A, type B and type non-A, non-B (NANB) hepatitis using needle biopsied specimens of the livers which were taken from patients with acute hepatitis (A 16, B 20, NANB 42), persistent hepatitis (B 40, NANB 21) and chronic active hepatitis (B 56, NANB 57). Some features characteristic to NANB heaptitis were obtained. They included (1) a poor regenerative activity and an indistinct boundary between regenerating area and necro-inflammatory area in acute hepatitis (2) a relatively loose cobblestone appearance of hepatocytes in persistent hepastitis and (3) a conspicious araphnoid and pericellular fibrosis, a vague nodularity of the parenchyma, a diffusely distributed mild to moderate necroinflammatory activity and small numbers of dysplastic cells in chronic active hepatitis. These caracteristics of NANB hepatitis are probably derived from a poor regenerating activity of hepatocytes.
社団法人日本肝臓学会の論文