Experimental studies of pulmonary edema in portal hypertention.

概要

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To evaluate the influence of portosystemic shunting on pulmonary edema that occur in men with portal hypertention, extra vascular lung water were measured in rats underwent portocaval anastomosis or rats of portal hypertension which caused by occulusion of portocaval anastomosis. Extra vascular lung water (ml/kg) was found to be increased in both models when compared with sham operated controls, but the increase in lung water was statistical in only rats with portal hypertention. The rats with portocaval anastomosis had a 100% shunt, while the rats with portal hypertention had a lesser degree of shunting, because hepatopetal collateral vessels developed due to portal hypertention. So it is suggested that not only portosystemic shunting but also portal hypertention per se is responsible for pulmonary edema in portal hypertention.
社団法人日本肝臓学会の論文