早期肝癌の病理形態学的研究-脂肪化について

概要

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In order to clarify the pathomorphologic significance of fatty change in hepatocellular carcinoma (HCC), 86 surgically resected HCCs smaller than 5cm in diameter were studied histologically. Among the 86 HCCs, fatty change was observed in 20 cases (23.3%), and was mainly found in welldifferentiated HCC. Fatty change was the most frequent (60.0%) in HCC ranged from 1.1 to 1.5cm in diameter. The incidence of fatty change decreased in accordance with the tumor diameter. According to the distribution pattern, fatty change was divided into diffuse type (6 cases) and focal type (14cases). Among the 25 HCCs larger than 3cm in diameter, fatty change of diffuse type was not seen. Fatty change of focal type was localized in a part or in the periphery of the tumor. Clear cell change of the cancer cells was also found in 13 (65.0%) of 20 HCCs with fatty change. Thus, fatty change was considered as one of pathomorphologic characteristics of minute HCC. It was predicted that fatty change of the tumor was caused by some metabolic disorder or circulatory disturbance which were localized in the tumor in the early stage.
社団法人日本肝臓学会の論文