エンドトキシンの肝細胞障害機序-特にクッパー細胞の役割

概要

論文の詳細を見る
The mechanism of hepatocyte dysfunction induced by endotoxin was investigated using a coculture system of hepatocytes and Kupffer cells from the view point of the role of Kupffer cell. During hepatocyte protein synthesis measurement, it was shown that endotoxin was capable of decreasing in the incorporation of 3H-leucine when the hepatocytes were cocultured with Kupffer cells. α-tocopherol, anti-tumor necrosing factor serumn (anti TNF), diltiazem and dexamethazone were respectively incapable of blocking the decrease, but superoxide dismutase, partially blocked the decrease in hepatocyte protein synthesis. The results indicated that the secretions raleased by Kupffer cells such as oxygen radicals excluding TNF, IL-I, arachnoid acid metabolite and protease, were assumed to be important in causing hepatocyte dysfunction induced by endotoxin.
社団法人日本肝臓学会の論文