C型肝炎ウイルスの配偶者間感染の実態について

概要

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We analized clinical background, serum transaminase, anti-HCV antibody (1st, 2nd ELISA, Ortho), Chiron new four-antigen recombinant immunoblot assay test (HCV RIBA II, Ortho) and HCV. RNA in 50 spouses who were married with anti-HCV antibody-positive patients with liver disease.<BR>Ten of 50 spouses (20%) were positive for both 1st and 2nd ELISA, 6 (12%) were positive for only 2nd ELISA, and 34 (68%) were both negative. Most of 1st ELISA-positive 10 cases were reactive of HCV RIBA II and positive for HCV-RNA with liver dysfunction. On the other hand, subclinical HCV infection (normal serum transaminase with positive reaction of c22-3) was observed in the only 2nd ELISA-positive cases. Mean age of the only 2nd ELISA-positive cases was 4.2 years younger than 1st ELISA-positive ones. Then, it was considered that the only 2nd ELISA-positive cases with HCV RIBA II-reactive might be compatible with asymptomatic HCV carrier state.<BR>These results suggested that the spouses of the anti-HCV antibody-positive patients with liverdisease were high risk group of HCV transmission.