Percutaneous acetic acid injection therapy for hepatocellular carcinoma less than 3cm in diameter.

概要

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Ultrasonically guided percutaneous acetic acid (15 to 40%) injection into tumor was performed in 48 patients with hepatocellular carcinoma(s) less than 3cm in diameter. After therapy the size of tumors decreased in all patients and 6 months later main tumor became undetectable by Ultrasound examination in 23 patients. Rebiopsy of main tumors was performed after therapy in 19 patients. Coagulation necrosis and fibrosis but no viable tumor cells were seen in all specimens. Two hepatocellular carcinomas obtained by partial resection at 6 and 20 months after therapy showed complete necrosis. Serum alpha-feto-protein level was reduced significantly after therapy in 4 patients with its high level before therapy. One-year, 2-year, 3-year and 4 year survival rate after therapy was 91%, 84%, 81%, and 61%, respectively. No significant side effects was seen. Thus, percutaneous acetic acid injection will be an effective therapy for small hepatocellular carcinoma(s).
社団法人日本肝臓学会の論文