Alterations of serum type IV collagen and 7-S domain concentrations after hepatectomy for hepatocellular carcinoma.

概要

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Fifteen hepatectomized patients with hepatocellular carcinoma (HCC group) and seven patients who underwent other abdominal operations (Control group) were measured for pre-and post-operative serum type IV collagen concentrations using two different methods; one was sandwich enzyme immunoassay (IV-C) and the other was radioimmunoassay (7-S).<BR>Compared with preoperative concentrations, IV-C significantly decreased immediately after operation, however, 7-S increased in both groups. In HCC group, from the first postoperative day (1 POD) to 14 POD, IV-C was significantly higher than preoperative concentration. On 1 and 3 POD, 7-S was significantly higher than preoperative concentration, however, it was restored on and after 7 POD. In HCC group, between the patients who suffered liver failure after operation and the patients who did not, there were no differences in alterations of postoperative IV-C or 7-S concentrations.<BR>These data show that IV-C reflects synthesis of type IV collagen and that 7-S reflects both its synthesis and degradation. It is useful to compare alterations of IV-C and 7-S concentrations to predict breakdown or repair of tissues. However, they do not correspond to the restoration of liver function after hepatectomy.
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