肝疾患におけるursodeoxycholic acid経口負荷試験の臨床的意義

概要

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The serum ursodeoxycholic acid disappearance rate following 25mg oral ursodeoxycholic acid by using radioimmunoassay (oral ursodeoxycholic acid tolerance test) was studied in 13 normal subjects and 58 patients with hepatocellar disease.<BR>In normal subjects the maximum ursodeoxycholic acid concentration was mostly noted 30 min after administration, and then serum ursodeoxycholic acid was rapidly cleared from blood. The delay of disappearance rate was remarkable or moderate in cirrhosis and chronic active hepatitis, significantly slight in chronic inactive hepatitis and variable in acute hepatitis. However, there was no correlation between this tolerance test and conventional liver function test except serum total bilirubin and ICG.<BR>The measurement of ursodeoxycholic acid disappearance rate sensitively reflected changes in hepatic function occuring with hepatocellar damege (especially, hepatic ursodeoxycholic acid uptake in chronic hepatic disease without arteriovenous shunt) and probably posess a clinical significance to assess the severity of hepatic diseases.
社団法人日本肝臓学会の論文