閉塞性黄疸における腎皮質ミトコンドリア機能について

概要

論文の詳細を見る
The standard kidney function and mitochondrial respiratory function in renal cortex were investigated in rats with biliary obstmtion, In addition an attmpt was made to determine the influence of hypotemsion and occlusion of renal artery on renal mitonchondrial function. The results are as follews. 1) The standard kidney function tests were identical with or with out existence of jaundice. 2) Respiratory control ratio, p/o, S3 and ATP synthesis of mitochondria were decreased proportionally to the duration of biliary obstruction. 3) Content of cytochrome a and cytochrome c in mitochondria was reduced with prolongadon of biliary obstruction. 4) Hypotension induced by exanguination did not alter standard renal function tests but caused significant reduction of mitochondrial for function, especially for cases with longterm biliary obstruction. 5) In rats with renal failure induced by occlusion of renal artery, the mitochondrial function deteriorated woth the prolongation of biliary obstruction. It is, therefore, suggested that patients with long-term biliary obstmction easily fall into renal failure associating with hypotension.
社団法人日本肝臓学会の論文