B型肝炎の経過に於ける肝組織内ウイルス関連抗原の変動--チンパンジ-における感染実験

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Temporal changes of HBc and HBs antigens within liver tissue were studied throughout the course of experimental HBV infbction in chimpanzees. The antigens were first found in liver cells, generally almost coincidentally with the development of HBs antigenemia, and very rarely befbre it. The detection of HBcAg tended to precede HBsAg in the tissue. The positivity of both antigens (in terms of number and intensity of staining of the positive liver cells or nucleus) was milder in rapidly resolving cases, while it was more marked in chronic or slowly resolving cases. In the former HBsAg was initially detected in the entire cytoplasma of rare single liver cells, which was followed by the membranepattern staining of grouped multiple liver cells befbre the elevation of transaminases in relatively severer cases. In the latter chronic cases the initial staining pattern was similarly fbund in the entire cytoplasm, but later it was characterized by cytoplasmic inclusion-body formation.
社団法人日本肝臓学会の論文