STUDIES ON FIBRINOLYTIC ENZYME SYSTEM IN DERMATOLOGY: LOCAL ANTIFIBRINOLYTIC ACTIVITY IN SEVERAL SKIN DISEASES

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In the studies herein reported, an attempt has been made to clarify the pathological physiology of local fibrinolytic enzyme system of the skin in patients suffered from several skin diseases. The investigation was performed by the examination of antifibrinolytic activity in the extract of skin of affected area, adopting modified Sasakis method to measure the inhibitory activity of skin extract upon the fibrinolytic activity in the extract of human maxillary sinus mucous membrane.The experimental dermatitis, resulted from broth culture of staphylococcus aureus and sterile filtrate of staph. broth culture, in guinea pig was also examined.The results of experiments showed the existence of anti-fibrinolytic activity in the extract of affected skin of chronic eczema, erythema exsudativum multi-forme, psoriasis vulgaris, pityriasis rosea Gibert and experimental dermatitis.Grateful acknowledgement is made to Prof. Dr. Okamoto, Director of Department of Physiology, Division I, Kobe Medical, Colledge. The assistance of the staff of Department of Physiology, School of Medicine, Keio University, is also gratefully acknowledged.
The Keio Journal of Medicineの論文