.ALPHA.-Adrenergic Blockade with Phenoxybenzamine Enhances Cerebrovascular CO2 Reactivity.
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概要
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The influence of sympathetic nervous activity on cerebral circulation and cerebrovascular CO2 reactivity was investigated by an α-adrenergic blockade with phenoxybenzamine (PBZ). Cerebral oxygen and carbon dioxide tension (BrPo2, BrPco2) and arterial blood pressure were continuously recorded before, during and after intracarotid infusion of 5 mg/kg of PBZ. The effects of 5% CO2 inhalation were measured before and after the infusion of PBZ. Following the intracarotid infusion of PBZ, BrPo2 and BrPco2 did not change significantly. After the α-adrenergic blockade the degree of the increase in BrPo2 during 5% CO2 inhalation was significantly enhanced. The increase in the cerebrovascular CO2 reactivity produced by low dose PBZ suggests that the sympathetic nervous system modifies cerebrovascular CO2 reactivity.
- The Keio Journal of Medicineの論文
著者
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五十棲 一男
Department Of Emergency And Critical Care Medicine
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福内 靖男
Department of Internal Medicine, School of Medicine, Keio University
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泉 義雄
Department of Internal Medicine, School of Medicine, Keio University
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五十棲 一男
Department of Neurology, School of Medicine, Keio University
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今井 明
Department of Neurology, Saiseikai Utsunomiya Hospital
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泉 義雄
Department of Neurology, School of Medicine, Keio University
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