Changes of Pial Vessel Diameter and CO2 Reactivity during Insulin-induced Hypoglycemia and in the Recovery Period following Glucose Administration.

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概要

• 論文の詳細を見る

• The present study examined the changes of cerebrovascular CO2 reactivity during insulin-induced hypoglycemia and in the recovery period following glucose administration in cats. The diameters of pial vessels were continuously measured using the vidicon camera system. Hypoglycemia was induced by intraperitoneal injection of ActrapidR insulin (100IU/kg). Cerebrovascular CO2 reactivity was estimated by the changes of pial vessel diameters during 3 min inhalation of 5% CO2 in air at each stage of glucose level. CO2 reactivity was impaired in the hypoglycemic stage and this impairment was further enhanced in the early recovery stage. In the late recovery stage, CO2 reactivity was restored particularly in the small arteries which were less innervated by autonomic nerves. These results suggest that the sympathetic activity plays an important role in the impairment of cerebrovascular CO2 reactivity during hypoglycemia.

• The Keio Journal of Medicineの論文

著者

• 五十棲 一男

  Department Of Emergency And Critical Care Medicine

• 福内 靖男

  Department of Internal Medicine, School of Medicine, Keio University

• 泉 義雄

  Department of Internal Medicine, School of Medicine, Keio University

• 今井 明

  Department of Neurology, Saiseikai Utsunomiya Hospital

• 畑 隆志

  Department of Internal Medicine, Kitasato University

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