Role of the Sympathetic System in Impairment of the Cerbrovascular CO2 Responsiveness during Moderate Hypoglycemia.
スポンサーリンク
概要
- 論文の詳細を見る
We examined the mechanism of impairment of the cerebrovascular CO2 responsiveness in moderate hypoglycemia. Twelve fasted cats were used. The brain-PO2, brain-PCO2 and brain-pH were measured continuously with electrodes placed on the brain surface. Hypoglycemia was induced with insulin. Intravenous injection of hexamethonium (a sympathetic ganglion blocker, C6; 0.1mg/kg) was performed at the following stages: Control, hypoglycemia and recovery. Before and after the C6 administration, 5%CO2 in air was inhaled for 3 min at the respective stages. The CO2 responsiveness (cerebrovascular dilatory response to increased PaCO2) at the control stage was not altered after the ganglionic blockade. At the hypoglycemic stage, the increase in BrPO2 by CO2 inhalation was significantly less than that at the control stage. This reduction of ΔBrPO2 was significantly improved after the administration of C6. At the recovery stage, the CO2 responsiveness before and after the administration of C6 was not significantly different. An impaired CO2 responsiveness in the hypoglycemic state was im-proved by sympathetic ganglion blockade with C6 which did not alter the reactivity during normoglycemia. It is suggested that the sympathetic activity plays an important role in impairment of the cerebrovascular CO2 responsiveness during moderate hypoglycemia.
- The Keio Journal of Medicineの論文
著者
-
五十棲 一男
Department Of Emergency And Critical Care Medicine
-
福内 靖男
Department of Internal Medicine, School of Medicine, Keio University
-
泉 義雄
Department of Internal Medicine, School of Medicine, Keio University
-
後藤 文男
Department of Internal Medicine, School of Medicine, Keio University
-
今井 明
Department of Neurology, Saiseikai Utsunomiya Hospital
-
畑 隆志
Department of Internal Medicine, Kitazato University
-
畑 隆志
Department of Internal Medicine, Kitasato University
関連論文
- Changes in Benzodiazepine Receptor Binding Detected with SPECT in Patients with Cerebral Infarction
- Rapid Changes in Pial Arterial Diameter and Cerebral Blood Flow Caused by Ipsilateral Carotid Artery Occlusion in Rats
- Rapid Reduction in Ryanodine Binding of Hippocampus CA1 in Cerebral Ischemia
- Swift Transformation and Locomotion of Polymorphonuclear Leukocytes and Microglia as Observed by VEC-DIC Microscopy : Video Microscopy
- Fluorometric Measurement of Intracellular pH in vivo in Feline Cerebral Cortex during Ischemia and Reperfusion
- Superacute Phase Blood Pressure Elevation May Relate to Massive Hematoma in Hypertensive Putaminal Hemorrhage
- Midpontine Tegmentum Infarction with “One-and-a-Half Syndrome” Demonstrated by Magnetic Resonance Imaging
- Paramyotonia Congenita without Cold Paralysis: A Case Report
- Mechanisms of CBF Augmentation during Hypoxia in Cats: Probable Participation of Prostacyclin, Nitric Oxide and Adenosine.
- Role of the Cyclooxygenase System in Cerebrovascular Responsiveness: Different Effects of Indomethacin on CO2 Responsiveness and Dilatation by Ca2+-channel Blocker.
- Spastic Paraplegia with Amyotrophy of the Legs: A Rare Case of Motor and Sensory Neuropathy.
- Influence of cerebral circulation on measurement of the cerebral glucose metabolic rate by 14C-deoxyglucose method.
- .ALPHA.-Adrenergic Blockade with Phenoxybenzamine Enhances Cerebrovascular CO2 Reactivity.
- Role of the Sympathetic System in Impairment of the Cerbrovascular CO2 Responsiveness during Moderate Hypoglycemia.
- Changes of Pial Vessel Diameter and CO2 Reactivity during Insulin-induced Hypoglycemia and in the Recovery Period following Glucose Administration.
- Validity of the operational equation of the 14C-deoxyglucose method modified for changing arterial plasma glucose level.