Glycosaminoglycans and collagen in skin of a patient with diabetic scleredema.
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概要
- 論文の詳細を見る
A 40-year-old Japanese male with diabetic scleredema was reported. Histochemical examination revealed that the alcian blue and colloidal iron strains were positive in the dermis, especially in the lower dermis. The biochemical analyses of the 3 horizontally sliced layers of scleredema skin revealed that (1) glycosaminoglycan content was low in the upper and middle dermis, which was chiefly due to the decrease in hyaluronic acid, (2) dermatan sulfate content was constant among the 3 layers, (3) the content of collagen in the upper and middle dermis was higher, and (4) the ratio of type I/type III collagen in the whole involved skin was normal. From these results, we speculate that the increase in collagen content in the upper and middle dermis may be essential for the pathophysiology of the disease.
- The Keio Journal of Medicineの論文
著者
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Nishikawa Takeji
Department Of Dermatology Keio University School Of Medicine
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Kawakubo Yo
Department Of Dermatology Tokai University
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Konohana Akira
Department Of Dermatology Saiseikai Yokohamashi Nanbu Hospital
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Kitamura Keijiro
Department Of Dermatology Saitama Medical Center Saitama Medical School
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Tajima Shingo
Department Of Dermatology Keio University
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TAJIMA SHINGO
Department of Dermatology, School of Medicine, Keio University
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TAJIMA Shingo
Department of Dermatiology, Keio University Schooh of Medicine
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