血漿採取用円盤型血漿分離器の性能

概要

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Development of donation plasmapheresis is urgent in Japan, where 25 % of the world's plasma fractions are consumed at present. In the present work, performance of a newly introduced disk-type membrane separator for donation plasmapheresis which was primarily devised for plasma exchange treatment for auto-immune disease patients was evaluated in constant-pressure experiments using bovine blood. From the results of these experiments over a wide range of wall shear rate (γω) and hematocrit (Hb), the following equation for volumetric flux through membrane (Jv) at radial distance from center (r) was obtained : Jv (r) =1.56×10-9γω (r) /r1/3ln (1.48/Hb (r)) Design of a plasma separator to satisfy the necessary condition (more than 4 × 10-4m3 plasma collection for 1800 s) was examined, using the above equation. Consequently, the optimum length, the inner diameter of the module, and the thickness and numbers of blood layers were determined for 0.15 m2 of membrane surface area.
社団法人化学工学会の論文