膠原病患者における抗リン脂質抗体の検討

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概要

• 論文の詳細を見る

• Antiphospholipid antibodies, antibodies to cardiolipin (CL) and to phosphatidyl serine (PS), were measured in the sera of 197 patients with various collagen diseases, including 108 patients with systemic lupus erythematosus (SLE), 29 patients with mixed connective tissue disease (MCTD), 39 patients with rheumatoid arthritis, 13 patients with Sjögren's syndrome and 8 patients with scleroderma. IgG anti-CL antibodies were found in 68 (63%) of SLE, 18 (62.1%) of MCTD, 13 (33.3%) of rheumatoid arthritis, 9 (69.2%) of Sjögren's syndrome, and 2 (25%) of scleroderma. IgG anti-PS antibodies were also found in 39 (36.1%), 15 (51.7%), 10 (25.6%), 9 (69.2%), and 1 (12.5%), respectively.In patients with SLE both antibodies were significantly related to thrombocytopenia, CNS lupus and spontaneous abortion. In patiens with MCTD there was a significant association between antiphospholipid antibodies and pulmonary hypertension. In patients with rheumatoid arthritis anti-CL antibody was significantly associated with positive antinuclear antibody, positive anti-SSA antibody and sicca symptom.

• 日本臨床免疫学会の論文

著者

• 菊池 正俊

  新潟大学第2内科

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