B-Cell expressing CD5 or activation antigens in the peripheral blood of Sjoegren's syndrome, rheumatoid arthritis and systemic lupus erythematosus.
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We determined CD5 antigen, interleukin-2 receptors (IL-2R) and transferrin receptors (TfR) on circulating B-cells in Sjögren's syndrome (SS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) by two-color flowcytometry.The proportions of total B-cells were significantly higher in 15 SLE patients and were relatively higher in 17 patients with primary (I°)-SS, 20 patients with secondary (II°)-SS and 24 patients with RA as compared with 22 controls. The proportion of CD5+ B-cells was also higher in I°-SS and RA than controls, although the cells were significantly decreased in SLE patients. However, the proportions of CD5+ B-cells in total B-cells were significantly low in II°-SS, RA and SLE. Most of the patients with SLE were receiving prednisolone (PSL) treatment, and the dosage of PSL administered was negatively correlated with the CD5+ B-cells in II°-SS patients.IL-2R+ B-cells were few and were within negligible range in any patients' groups, but the proportions of TfR+ B-cells were significantly high in the patients' groups, except for RA. TfR+ B-cells seemed to reflect the activity of diseases, since they positively correlated with the dosage of PSL in the patients.Among the B-cells determined, the increase of total B-cells, CD5+ B-cells and TfR+ B-cells was proportional in only RA patients.Our results, therefore, did not support the previous reports showing increased CD5+ B-cells in RA, SS or SLE patients. In addition, the results indicate that CD5 antigen might not be an activation antigen of B-cells, although the stimulations to B-cells might be different among patient's groups.
- 日本臨床免疫学会の論文
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