Studies on dipeptidyl aminopeptidase IV(DAP IV) in human peripheral lymphocytes.

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概要

• 論文の詳細を見る

• Dipeptidyl aminopeptidase IV (DAP IV) has been demonstrated localizing in certain human T cell. In vitro mitogen stimulations (PHA, Con A and PWM) was employed to assess possible participation of lymphocyte DAP IV in immune responses.In healthy human peripheral lymphocytes, mitogen stimulations produced a marked increase in DAP IV activities; and similar increase was observed also in culture supernatant. In addition, those phenomena paralleled with increase in released soluble IL-2 receptor.The principal action of DAP IV remained unknown, but it might, with its connection to production of IL-2 receptor, be part of a correlating mechanism having to do with an immune regulatory system.Clinical data from the patients with Behcet's disease, rheumatoid arthritis and systemic lupus erythematosus were discussed in a comparable manner.

• 日本臨床免疫学会の論文

著者

• 加来 秀彦

  神奈川県総合リハビリテーション研究・研修所研究部障害医学研究室

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• Studies on dipeptidyl aminopeptidase IV(DAP IV) in human peripheral lymphocytes.

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