Alteration of complement value in healthy male subjects. Long term observation in 9 healthy male subjects.:Long term observation in 9 healthy male subjects

概要

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Total hemolytic complement (CH 50) and the serum levels of C3 and C4 were measured in 9 healthy male subjects for three months every week, in order to demonstrate the intra-individual variation in healthy subjects.The mean values of intra-individual physiological variations in 9 subjects were as follows; CH 50: Standard Deviation (SD) 2.0unit/ml and Coefficient of Variation (CV) 5.0%, C3: SD 14% and CV 10%, and C4: SD 15% and CV 12%.There was no correlation between CH 50 and the serum levels of C3 and C4. Hypocomplementemia was not seen. Elevated levels of CH 50 were observed in 5 subjects when they showed signs of common cold.It may be important in assessing alterations of complement value in various disease states to consider about such intra-individual variations of complement in healthy subjects.
日本臨床免疫学会の論文