Gamma-globulin therapy to whooping cough I:Treatment of whooping cough with S-sulfonated gamma-globulin

概要

論文の詳細を見る
The present investigation was designed to evaluate the efficacy of S-sulfonated gamma-globulin (S-GG), of which interchain disulfide bonds were selectively cleaved to give S-sulfonate groups. When S-GG is intravenously administered, it gradually reconverts into the original gamma-globulin (GG) and decays with half-life of about 24 days, comparable to that of GG.Children with whooping cough were divided into two groups, one consisted of 37 cases (male: female=15: 22) received the combined therapy with S-GG (100 to 120 mg/kg, intravenous administration with drip infusion.) and antibiotics, and the other consisted of 52 cases (male: female=25: 27) treated with antibiotics alone.Bronchodilators and cough remedy were given orally to all patients. The improvement of cough and the decreasing rate of lymphocyte per day were compared between two groups, and following results were obtained. 1. The improvement of coughing in the combined therapy group of S-GG and antibiotics was superior significantly to that in antibiotics therapy group in total cases. The similar results were observed not only in patients with severe cough (frequent paroxysms with cyanosis and/or apnea), but also in patients with moderate (frequent paroxysms) to mild (not so frequent paroxysms) cough. 2. The decreasing rate of lymphocytes in combined therapy group was higher than that of antibiotics therapy group either in the cases with lymphocyte counts of more than 15, 000/mm3, or in that of less than 15, 000/mm3. It was concluded that the combined therapy with S-GG and antibiotics to whooping cough was of value. The reducing effect to lymphocytosis by S-GG suggests to be the neutralizing activity to leukocytosis or lymphocytosis promoting factor produced by B. pertussis.
日本臨床免疫学会の論文

Gamma-globulin therapy to whooping cough I:Treatment of whooping cough with S-sulfonated gamma-globulin

スポンサーリンク

概要

著者

関連論文

スポンサーリンク