Basophil reactivity to anti-IgE and allergen in asthmatic subjects: relation to house dust allergy

概要

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Basophil reactivity to anti-IgE and house dust extract was examined in 69 patients with bronchial asthma by measuring the amount of histamine release.1. Histamine release by anti-IgE varied widely in the cases with a RAST score from 0+ to 1+ and low serum IgE levels. Basophil reactivity to anti-IgE in the cases with a RAST score of 2+ tended to increase as serum IgE levels increased, although there was no significant correlation between them. The cases with a RAST score of 3+ generally showed a high reactivity to anti-IgE regardless of serum IgE levels.2. There was no positive correlation between histamine release by house dust extract and serum IgE levels.3. Histamine release by anti-IgE was similar to that by house dust extract in the cases with a RAST score of 2+ and 3+.
日本臨床免疫学会の論文