Studies of Mammalian Implantation <I>In Vitro</I> (I): Production of Laminin from Human Decidual Cell Line and Its Effects on Murine Trophoblastic Outgrowth
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概要
- 論文の詳細を見る
TTK-1 cell line from human first trimester decidual tissue carried the surface markers such as HNK-1 (Leu 7) and HLA-DR. This cell line was strongly suspected of being human natural suppressor cell line of bone marrow or lymphoid tissue origin. In addition, the cells were found to express laminin on its cell surface, as examined by indirect immunofluorescence (IIF) test, and also secrete it into culture supernates as examined by enzyme linked immunoassay (EIA) and immunostaining. The addition of the supernates from this cell line into the murine embryo culture induced the trophoblastic outgrowth of embryos <I>in vitro</I> in the same manner as murine EHS sarcoma derived laminin did. This phenomenon was considered to be due to laminin in the UK-1 supernates because the effect was completely blocked by the addition of anti-laminin antibodies into the embryo culture.
- 日本繁殖生物学会の論文
著者
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ISEMURA MAMORU
Department of Food and Nutritional Sciences, University of Shizuoka
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Mori Etsuko
Department Of Dermatology Faculty Of Medicine University Of Tokyo
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Isemura Mamoru
Department Of Cellular Biochemistry School Of Food And Nutritional Sciences University Of Shizuoka
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Mori Tsuneatsu
Department Of Immunology Institute Of Medical Science University Of Tokyo
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GUO Mao
Department of Immunology, Institute of Medical Science, University of Tokyo
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TAKADA Mito
Department of Immunology, Institute of Medical Science, University of Tokyo
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Mori Tsuneatsu
Department Of Biochemistry Institute Of Medical Science University Of Tokyo
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Mori Etsuko
Department Of Biochemistry Institute Of Medical Science University Of Tokyo
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- Studies of Mammalian Implantation In Vitro (I): Production of Laminin from Human Decidual Cell Line and Its Effects on Murine Trophoblastic Outgrowth
- Studies of Mammalian Implantation In Vitro (II): Effects of Cytokines from Mixed Lymphocyte Reaction on Proliferation of Murine Trophoblast Cell and Establishment of Its Cell Line
- Purification of N-acetyllactosamine-binding Activity from the Porcine Sperm Membrane : Possible Involvement of an ADAM Complex in the Carbohydrate-binding Activity of Sperm
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