Visualization of Renal Micro circulation in Isolated Munich-Wistar Rat Kidneys: Effects of Endothelin-1 on Renal Hemodynamic Activity

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概要

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• The aim of the present study was to visualize the superficial glomeruli of the Munich-Wistar (MW) rat and to characterize the responses of the renal microvasculature to endothelin-1 (ET-1). We first examined the distribution of superficial glomeruli of the MW rat compared to that in a control strain (Wistar rat). Secondly, we examined the effects of ET-1 on the renal microcirculation of the MW rat. The right kidney was perfused with a Krebs-Ringer solution containing fluorescein isothiocyanate dextran (FITC-dextran) and was visualized under an epi-illuminated fluorescence microscope system. Changes in perfusion pressure and diameter of the microvessels accompanying the administration of ET-1 (10 fmole-300 pmole) were measured. The number of superficial glomeruli was greater in the MW rat than in the Wistar rat. ET-1 had long-lasting and dose-dependent pressor effects. Perfusion pressure showed a 3.5-fold increase compared with the control, and the afferent arterioles showed greater dose-dependent vasoconstriction than the efferent arterioles. These findings suggest that the MW rat is a useful animal model for the study of renal microcirculation and that the renal microcirculation is extremely sensitive to ET-1.

著者

• Saito Mamoru

  Tsukuba Research Laboratories Eisai Co. Ltd.

• Ohshima Norio

  Department Of Biomedical Engineering Institute Of Basic Medical Sciences University Of Tsukuba

• Homma Satoshi

  Department Of Cardiovascular Division Institute Of Clinical Medicine University Tsukuba

• Sato Masaaki

  Department Of Anesthesiology Jichi Medical School

• Yamatsu Isao

  Tsukuba Research Laboratories, Eisai Co., Ltd.

• Homma Satoshi

  Department of Biomedical Engineering, Institute of Basic Medical Sciences, University of Tsukuba

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