EFFECTS OF CHRONIC ADMINISTRATION OF KANAMYCIN ON CONDITIONED SUPPRESSION TO AUDITORY STIMULUS IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
The conditioned suppression technique was employed to study the ototoxic effects of chronic administration of the antibiotic, kanamycin. Lever pressing behavior for food reinforcement of rats was suppressed in the presence of an auditory stimulus (sound) or visual stimulus (light) that had been previously paired with electric shocks. Repeated administration of kanamycin at the dose of 400 mg/kg/day for more than 50 days significantly attenuated the conditioned suppression to auditory stimulus but did not attenuate the conditioned suppression to visual stimulus. This finding suggests that the attenuating effect of chronic administration of kanamycin on conditioned suppression to auditory stimulus can be interpreted in terms of the selective action of the drug on the auditory system.
- 社団法人 日本薬理学会の論文
著者
-
CHIBA Sukehiro
Drug Safety Research Centre, Central Research Division, Takeda Chemical Industries, Ltd.
-
Ando Kiyoshi
Department Of Hematology And Oncology Tokai University School Of Medicine
-
Ando Kiyoshi
Department Of Hematology And Oncology Tokai University
関連論文
- Comparative analysis of remission induction therapy for high-risk MDS and AML progressed from MDS in the MDS200 study of Japan Adult Leukemia Study Group
- Persistence of derivative chromosome 22 after achieving a major molecular response in chronic myeloid leukemia with a cryptic BCR-ABL1 fusion gene
- Phase I and II pharmacokinetic and pharmacodynamic study of the proteasome inhibitor bortezomib in Japanese patients with relapsed or refractory multiple myeloma
- Non-hematopoietic Mesenchymal Stem Cells can be Mobilized and Differentiate into Cardiomyocytes after Myocardial Infarction(Development and Differentiation 3 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Transplanted Bone Marrow Stem Cells Move to the Infarcted Myocardium and Regenerate the Heart
- Comparison of leukopenia between cytarabine and behenoyl cytarabine in JALSG AML-89 consolidation therapy
- No beneficial effect from addition of etoposide to daunorubicin,cytarabine,and 6-mercaptopurine in individualized induction therapy of adult acute myeloid leukemia:the JALSG-AML92 study
- Prognostic Significance of FLT3 Internal Tandem Duplication and NPM1 Mutations in Acute Myeloid Leukemia in an Unselected Patient Population
- Prospective isolation of regenerated cardiomyocytes from the mixture of mesenchymal stem cells
- Combination Chemotherapy With Risk Factor-Adjusted Dose Attenuation for High-Risk Myelodysplastic Syndrome and Resulting Leukemia in the Multicenter Study of the Japan Adult Leukemia Study Group (JALSG): Results of an Interim Analysis
- Mechanisms of retinoid resistance in a myeloid cell line, YM711,transfected with PML/RARα cDNA : possible involvement of redox potential
- Changes in Microbial Flora in Neutropenic Patients With Hematological Disorders After the Hanshin-Awaji Earthquake
- Myelodysplastic syndrome with B cell clonality in a patient five years after renal transplantation
- Recombinant human erythropoietin for late-onset anemia after allogeneic bone marrow transplantation
- Correlation between immunological abnormalities and prognosis in myelodysplastic syndrome patients
- Detection of donor-type alveolar macrophages in transplantation with highly purified CD34^+ bone marrow cells
- Myelodysplastic changes in three cases within 100 days after allogeneic bone marrow transplantation
- CORRELATION BETWEEN SEVERITY OF PARKINSONISM AND DOPAMINE NEURONAL DAMAGE IN MPTP-TREATED MARMOSETS
- Ex vivo evidence for asymmetric tyrosine phosphorylation of ZAP-70 on double-positive thymocytes in the positive selection process
- Extramedullary Blast Crisis Derived from 2 Different Clones in the Central Nervous System and Neck during Complete Cytogenetic Remission of Chronic Myelogenous Leukemia Treated with Imatinib Mesylate
- Follicular Lymphoma in Osaka, Japan : Histological Features and Chronological Change
- A Case of Hypoplastic Chronic Myelogenous Leukemia Initiating With Pancytopenia
- 3 Lesson from GFP^+ bone marrow transplanted mice : Regeneration of infarcted myocardium by cytokine administration(Symposium 8 (SY8) (M) : Regeneration Medicine of Cardiovascular Diseases)(Special Program)
- 3-Dimensional Coronary Angiography in Mice Using Confocal : Laser Scanning Microscopy
- Possible involvement of the TGF-β1 signal in the development of peritoneal sclerosis as one of the major complications in continuous ambulatory peritoneal dialysis
- Serum KL-6 Levels in Patients With Pulmonary Complications After Allogeneic Bone Marrow Transplantation
- Ikk-i, a novel Lipopolysaccharide-inducible kinase that is realted to lκB Kinases
- Concurrent Murine Cytomegalovirus and Klebsiella pneumoniae Infections in Germfree Mice
- Immunological Responses in Germfree Mice Infected with Murine Cytomegalovirus
- Phase II study of oral fludarabine in combination with rituximab for relapsed indolent B-cell non-Hodgkin lymphoma
- Eosinophilic Colitis in a Patient with Acute Myeloid Leukemia after Allogeneic Bone Marrow Transplantation
- Human CD34^- Hematopoietic Stem Cells: Basic Features and Clinical Relevance
- TOLERANCE AND CROSS TOLERANCE TO TOXIC EFFECTS OF MORPHINE, METHADONE AND 1-ALPHA-ACETYLMETHADOL (LAAM) IN NAIVE AND MORPHINE DEPENDENT RAT
- Characteristics of CD5-Positive Splenic Marginal Zone Lymphoma with Leukemic Manifestation ; Clinical, Flow Cytometry, and Histopathological Findings of 11 Cases
- Phase I study of the oral mammalian target of rapamycin inhibitor everolimus (RAD001) in Japanese patients with relapsed or refractory non-Hodgkin lymphoma
- EFFECTS OF CHRONIC ADMINISTRATION OF KANAMYCIN ON CONDITIONED SUPPRESSION TO AUDITORY STIMULUS IN RATS
- Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria : the AEGIS Clinical Trial
- Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia : a retrospective safety analysis
- Romiplostim for the treatment of chronic immune thrombocytopenia in adult Japanese patients : a double-blind, randomized Phase III clinical trial
- An open-label extension study evaluating the safety and efficacy of romiplostim for up to 3.5 years in thrombocytopenic Japanese patients with immune thrombocytopenic purpura (ITP)
- Effects of Psychoactive Drugs on Short-Term Memory in Rats and Rhesus Monkeys.