EFFECTS OF HYDROXYLAMINE, SODIUM NITRITE, AMMONIUM SULFATE AND ETHANOL ON DIAMINE OXIDASE OF HOG KIDNEY
スポンサーリンク
概要
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Enzymic properties of diamine oxidase (DAO) and histaminase were compared. The enzymic activities of a partially purified preparation from hog kidney were determined by measuring oxygen consumption using cadaverine and histamine as substrates for DAO and histaminase, respectively. Differences were found in the effects of various reagents on the two activities. Although NH<SUB>2</SUB>OH inhibited to a similar extent the activities of DAO and histaminase, NaNO<SUB>2</SUB>, (NH<SUB>4</SUB>)<SUB>2</SUB>SO<SUB>4</SUB> and C<SUB>2</SUB>H<SUB>5</SUB>OH affected the two activities differently. Moreover, NH<SUB>2</SUB>OH and NaNO<SUB>2</SUB> had no effects on the pS curves of the two enzymes. (NH<SUB>4</SUB>)<SUB>2</SUB>SO<SUB>4</SUB> and C<SUB>2</SUB>H<SUB>5</SUB>OH had no effect on the pS maximum of histaminase, but shifted the pS maximum to a higher concentration of cadaverine. Furthermore, marked differences in the mechanisms of action of DAO and histaminase were apparent from the effects of NH<SUB>2</SUB>OH, NaNO<SUB>2</SUB>, (NH<SUB>4</SUB>)<SUB>2</SUB>SO<SUB>4</SUB> and C<SUB>2</SUB>H<SUB>5</SUB>OH on the two activities as measured from Lineweaver-Burk plots. These results indicate that the enzymic properties of DAO and histaminase are different and suggest that they are probably different enzymes.
- 社団法人 日本薬理学会の論文
著者
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Kaneko Osamu
Department Of Molecular Parasitology Ehime University Graduate School Of Medicine
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KANEKO Osamu
Departments of Pharmacology and Dermatology, School of Medicine, Showa University
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