STUDIES ON A NEW 1, 5-BENZOTHIAZEPINE DERIVATIVE (CRD-401) : V. ANTIARRHYTHMIC ACTIONS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of CRD-401 on several types of experimentally induced arrhythmias in guinea-pigs and dogs and the antagonistic effect against isoproterenol in the isolated atrium of guinea-pig were studied and compared with quinidine and propranolol. In epinephrine-induced arrhythmias of guinea-pigs, propranolol had a notable but brief depressive effect, which was observed only 5 min after administration of the drug. Although the potency of CRD-401 was weaker than that of propranolol in these arrhythmias, the effect persisted for more than 35 min after administration. In ouabain-induced arrhythmias of guinea-pigs, CRD-401 and propranolol showed similar depressive effects. Quinidine had little effect on both epinephrine- and ouabain-induced arrhythmias. Both CRD-401 and propranolol failed to reverse the arrhythmias produced by two-stage coronary artery ligation. Propranolol showed a competitive antagonism against the positive chronotropic effect of isoproterenol, while CRD-401 revealed a non-competitive β-blocking action. Quinidine produced no blocking effect in the present experiments.
- 社団法人 日本薬理学会の論文
著者
-
Nakajima Hiromichi
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
-
Yamada Kenji
Biological Institute Faculty Of Science Toyama University
-
SHIMAMURA Takashi
Biological Research Laboratory, Tanabe Seiyakrr Co., Ltd.
-
NAKAJIMA Hiromichi
Biological and Chemical Reseach Labolatories, Tanabe Seiyaka Co., Ltd.
-
NAKAJIMA Hiromichi
Biological Research Laboratory, Tanabe Seiyakrr Co., Ltd.
関連論文
- Effects of Vanadium Ions in Different Oxidation States on Myosin ATPase Extracted from the Solitary Ascidian, Halocynthia roretzi (Drasche) : Biochemistry
- Regular Articles
- EFFECT OF A NEW ANTICHOLINERGIC AGENT (SA-504) ON MOTILITY OF THE GASTROINTESTINAL TRACT AND THE URINARY BLADDER IN CATS
- STUDIES ON A NEW 1, 5-BENZOTHIAZEPINE DERIVATIVE (CRD-401) III. EFFECTS OF OPTICAL ISOMERS OF CRD-401 ON SMOOTH MUSCLE AND OTHER PHARMACOLOGICAL PROPERTIES
- STUDIES ON A NEW 1, 5-BENZOTHIAZEPINE DERIVATIVE (CRD-401) : II. VASODILATOR ACTIONS
- BRONCHOCONSTRICTOR EFFECT OF HISTAMINE IN CATS
- EFFECTS OF DILTIAZEM ON THE POSITIVE INOTROPIC AND VASOCONSTRICTOR RESPONSES TO OUABAIN IN VITRO
- EFFECT OF DILTIAZEM ON THE MEMBRANE POTENTIAL OF UTERINE SMOOTH MUSCLE
- EFFECT OF DILTIAZEM ON INSULIN SECRETION I. EXPERIMENTS IN VITRO
- BRONCHODILATING ACTIONS OF (±)-1-(3, 4, 5-TRIMETHOXY-BENZYL)-I, 2, 3, 4-TETRAHYDROISOQUINOLINE (TMI) DERIVATIVES IN ANESTHETIZED CATS
- STUDIES ON A NEW 1, 5-BENZOTHIAZEPINE DERIVATIVE (CRD-401) : V. ANTIARRHYTHMIC ACTIONS
- STUDIES ON TETRAHYDROISOQUINOLINES (THI) (VIII) PHARMACOLOGICAL PROPERTIES OF METABOLITES OF A NEW ADRENERGIC β-STIMULANT, TRIMETOQUINOL
- Effect of GTP on the affinity of denopamine, a new cardiotonic agent, for .BETA.-adrenergic receptors of turkey erythrocytes and rat reticulocyte membranes.
- Cardiovascular effects of a new positive inotropic agent, (-)-(R)-1-(p-hydroxyphenyl)-2-((3,4-dimethoxyphenethyl)amino)-ethanol (TA-064) in the anesthetized dog and isolated guinea pig heart.
- Cardiovascular effects and plasma levels of denopamine (TA-064), a new positive inotropic agent, in chronically instrumented dogs.
- Studies on the affinity and selectivity of denopamine (TA-064), a new cardiotonic agent, for .BETA.-adrenergic receptors.