STUDIES ON A NEW 1, 5-BENZOTHIAZEPINE DERIVATIVE (CRD-401) III. EFFECTS OF OPTICAL ISOMERS OF CRD-401 ON SMOOTH MUSCLE AND OTHER PHARMACOLOGICAL PROPERTIES
スポンサーリンク
概要
- 論文の詳細を見る
3-Acetoxy-2, 3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1, 5-benzothiazepin-4(5H)-one hydrochloride is a now compound having a strong coronary vasodilator activity (1). Its vasodilator action on the coronary as well as femoral artery was found to be stereospecific for the <I>d</I>-cis-isomer (CRD-401). It is inferred that the new 1, 5-benzothiazepine derivative and its stereoisomers exert their effects by acting directly on the blood vessels (2).<BR> In the present study, the effects of <I>d</I>-, <I>dl</I>- and <I>l</I>-cis-isomers of the compound were investigated on the isolated smooth muscle of guinea pig. The general pharmacological properties of these compounds were also studied in various experimental animals.
- 社団法人 日本薬理学会の論文
著者
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Sato Masanori
Biology Division, National Cancer Center Research Institute
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Nagao Taku
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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Nakajima Hiromichi
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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IWASAWA Yoshio
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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TAKADA Toshikazu
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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ISHIDA Ryuichi
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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KIYOMOTO Akio
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.
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SATO Masanori
Biological and Chemical Reseach Labolatories, Tanabe Seiyaka Co., Ltd.
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KIYOMOTO Akio
Biological and Chemical Research Laboratories, Tanabe Seiyaku Co., Ltd.
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NAKAJIMA Hiromichi
Biological and Chemical Reseach Labolatories, Tanabe Seiyaka Co., Ltd.
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NAGAO Taku
Biological Research Laboratories, Tauabe Seiyaku Co., Ltd.
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KIYOMOTO Akio
Biological and Chemical Reseach Labolatories, Tanabe Seiyaka Co., Ltd.
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